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rifampin will lessen the extent or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.Keep track of Closely (one)istradefylline will raise the level or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.Influence of coadministration of the twin CYP3A4 and CYP2C19

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